![]() Into membrane so that the N-terminus of the protein is exoplasmic. Describe two mechanisms for cotranslational insertion of a single-pass protein.Describe a model that would account for the cotranslational insertion ofĪ single-pass protein into membrane so that the N-terminus of the protein.If a single-pass membrane protein has an internal signal sequence, whatĭetermines whether the N-terminus of the mature protein will be cytosolic.What is "BiP"? Describe the role of BiP in posttranslational insertion.(Indicate the names of the "motor" proteins or protein complexes for each case.) Compare general modes of action of the "motors" used by eukaryotic systems and bacterial systems for posttranslational translocation of proteins across the ER membrane (eukaryotes) and the cytoplasmic membrane(bacteria).Types of factors determine which role will be played by a translocon at any Proteins into the ER lumen, posttranslational insertion of proteins into theĮR lumen, and elimination of improperly folded proteins from the ER, what Given that the Sec61 complex participates in cotranslational insertion of.In the ER lumen:(a) calnexin, (b) protein disulfide isomerase, and (c) glycosyl ![]()
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